Reticular pseudodrusen (RPD) has recently been identified as a particular yellowish interlacing network of oval or round lesion in the fundus of aged retinal degeneration patients. RPD can be easily misdiagnosed as typical drusen. However, a large number of observations indicated that RPD and typical drusen are different in distribution, morphological features and pathophysiological processes. The diagnosis of RPD relies on multiple fundus examinations including fundus autofluorescence, infrared reflectance and spectral-domain optical coherence tomography. RPD may be associated with age-related macular degeneration, choroidal neovascularization and geographic atrophy, but the prevalence of RPD is found low in polypoidalchoroidalvasculopathycases. Differential diagnosis of RPD and drusen may affect the treatment and prognosis of these conditions. Thus a careful long-term follow-up is mandatory for these patients.