The heme oxygenase/biliverdin reductase system in skin cancers.
Copyright policy )The heme oxygenase/biliverdin reductase system in skin cancers.
The heme oxygenase/biliverdin reductase (HO/BVR) pathway enhances cell stress response by degrading excess heme or producing antioxidant and cytoprotective molecules. Recently, members of the HO/BVR system have been proposed as biomarkers for the early diagnosis of free radical-related diseases. In this study, the presence of both the inducible and constitutive HO isoforms (HO-1 and HO-2, respectively) and BVR was evaluated by immunohistochemistry in human skin cancer samples. Moderate/strong immunoreactivities against HO-1, HO-2 and BVR were detected in 100% of the nodular malignant melanoma samples, whereas in basal cell carcinoma specimens these figures were 62%, 88% and 60%, respectively, with a faint/moderate degree of expression. Faint/moderate HO-1, HO-2 and BVR immunoreactivities were detected in 33%, 66% and 100% of melanocytic nevi samples, respectively. In conclusion, HO-1 and HO-2 and BVR were expressed in the cytosols of skin cancer cells, whereas perilesional normal epidermis showed only faint staining, thus leading to the hypothesis that the HO/BVR system is activated in skin cancers.
Adult, Male, Oxidoreductases Acting on CH-CH Group Donors, Skin Neoplasms, Cell stress response, Middle Aged, Cytosol, Heme oxygenase-1, Heme Oxygenase (Decyclizing), Biomarkers, Tumor, Humans, Female, Basal Cell Carcinoma, Melanoma, Heme Oxygenase-1, Aged
Adult, Male, Oxidoreductases Acting on CH-CH Group Donors, Skin Neoplasms, Cell stress response, Middle Aged, Cytosol, Heme oxygenase-1, Heme Oxygenase (Decyclizing), Biomarkers, Tumor, Humans, Female, Basal Cell Carcinoma, Melanoma, Heme Oxygenase-1, Aged
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!