Trilateral retinoblastoma in transgenic mice.
Copyright policy )Trilateral retinoblastoma in transgenic mice.
Retinoblastoma, a heritable malignancy, occurs in the eyes of children at a median age of 2 years. It is a malignancy which has been widely studied as a model for genetic predisposition to cancer. The disease occurs in both heritable and nonheritable forms. Thirty to 40% of children with retinoblastoma have a heritable form of the disease. The other 60% to 70% of affected children have spontaneous somatic mutations which will not be transmitted to their own offspring.
- Utrecht University Netherlands
Brain Neoplasms, Eye Neoplasms, Retinoblastoma, Gene Expression, Mice, Transgenic, Simian virus 40, Luteinizing Hormone, Transfection, Blotting, Southern, Disease Models, Animal, Mice, Animals, Biologie, Polymorphism, Restriction Fragment Length
Brain Neoplasms, Eye Neoplasms, Retinoblastoma, Gene Expression, Mice, Transgenic, Simian virus 40, Luteinizing Hormone, Transfection, Blotting, Southern, Disease Models, Animal, Mice, Animals, Biologie, Polymorphism, Restriction Fragment Length
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