The contemporary orthodontics should highlight the periodical control of growth and dental development in order to intercept possible disorders in facial growth and tooth eruption. This may allow avoidance or simplification of corrective orthodontic treatment, making it faster and less aggressive. Tooth transposition, a genetically determined eruptive disturbance, presents a relatively low prevalence in the world population and primarily affects maxillary canines and premolars. This paper presents an option for interceptive treatment of bilateral transposition of maxillary canine and premolar diagnosed early in a young individual. Longitudinal follow-up of RME performed in adequate timing to redirect the eruption pathway of permanent maxillary canines is presented.