[Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities].
Copyright policy )[Study on steroidal saponins from Dioscorea zingiberensis and their platelet aggregation activities].
Using the absorbent resin, silica gel and ODS column chromatography as well as semi-preparative HPLC, ten compounds were isolated from 70% ethanol extract of tubers of Dioscorea zingiberensis C. H. Wright, and their structures were elucidated as trigoneoside XIIIa (1), parvifloside (2), trigoneoside IVa (3), deltoside (4), protobioside (5), lilioglycoside k (6), zingiberensis newsaponin I (7), deltonin (8), prosapogenin A of dioscin (9), and trillin (10) on the basis of NMR and MS spectral data analysis. Among these compounds, 1, 3, 5 and 6 were isolated from this plant for the first time. In the screening test on platelet aggregation, compounds 7 and 8 exhibited induction effect on platelet aggregation, while compound 9 exhibited significant inhibitory effect on platelet aggregation in vitro.
Male, Molecular Structure, Platelet Aggregation, Dioscorea, Saponins, Mass Spectrometry, Rats, Animals, Rats, Wistar, Drugs, Chinese Herbal
Male, Molecular Structure, Platelet Aggregation, Dioscorea, Saponins, Mass Spectrometry, Rats, Animals, Rats, Wistar, Drugs, Chinese Herbal
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