QSAR analysis of chiral compounds including racemates.
Copyright policy )QSAR analysis of chiral compounds including racemates.
From equations describing dose/response curves of drug combinations the nonlinear dependence of the ECx value (concentration for X% effect) of a racemate on the ECx values of the pure enantiomers was derived. This equation was used in QSAR analyses of series of substances containing pure compounds (i.e. pure enantiomers or achiral molecules) and stereoisomeric mixtures.
Dose-Response Relationship, Drug, Receptors, Opioid, kappa, Guinea Pigs, Brain, Muscle, Smooth, In Vitro Techniques, Models, Theoretical, Acetylcholine, Rats, Kinetics, Structure-Activity Relationship, Jejunum, Isomerism, Drug Design, Receptors, Opioid, Animals, Cholinesterase Inhibitors, Mathematics
Dose-Response Relationship, Drug, Receptors, Opioid, kappa, Guinea Pigs, Brain, Muscle, Smooth, In Vitro Techniques, Models, Theoretical, Acetylcholine, Rats, Kinetics, Structure-Activity Relationship, Jejunum, Isomerism, Drug Design, Receptors, Opioid, Animals, Cholinesterase Inhibitors, Mathematics
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