Nosocomial myiasis is an infestation by fly larvae that occurs while a patient is hospitalized. To analyze the available information on nosocomial myiasis in Latin America and the Caribbean, a search was done for cases published in the last 52 years. Nine clinical cases were found for Brazil, Costa Rica, French Guiana, Honduras, and Jamaica. Two other publications mention 139 cases in El Salvador and some 32 in Colombia, respectively. The patients and environments described presented conditions that predispose to this type of infestation. Compulsory notification is not usually required for nosocomial myiasis in Latin America and the Caribbean, meaning that there is probably considerable underreporting. Awareness needs to be raised and registry improved of myiasis in the region to aid in adoption of better prevention measures, which will benefit patient care during hospitalization.