[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].

T S, Gan'shina; G A, Kim; A V, Gnezdilova; I N, Kurdiumov; R S, Mirzoian

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Экспериментальная и ...arrow_drop_down

Экспериментальная и клиническая фармакология

Article . 2014

Data sources: Europe PubMed Central

[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].

descriptionPublicationkeyboard_double_arrow_right Article 19 Dec 2014 Russian Journal:Eksperimental'naia i klinicheskaia farmakologiia, volume 77 (issn: 0869-2092,

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Authors: T S, Gan'shina; G A, Kim; A V, Gnezdilova; I N, Kurdiumov; R S, Mirzoian;

pmid: 25365862

[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].

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Abstract

We have performed a comparative study of the effects of S-amlodipine nicotinate and nimodipine on the local cerebral blood flow were studied in intact rats and those with model ischemic and hemorrhagic brain injury. It is established that S-amlodipine nicotinate produces a somewhat more pronounced enhancement of cerebral blood flow in rats with ischemic and hemorrhagic brain injury than in intact animals. In addition, S-amlodipine nicotinate significantly exceed nimodipine with respect to cerebrovascular activity in rats with brain pathology of both ischemic and hemorrhagic nature.

Keywords

Male, Microcirculation, Vasodilator Agents, Brain, Brain Edema, Niacin, Brain Ischemia, Rats, Brain Injuries, Animals, Outbred Strains, Laser-Doppler Flowmetry, Animals, Nimodipine, Amlodipine

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