We conducted a study to determine if there is a significant difference in ultimate load, yield strength, and fatigue strength between solid core screws and cannulated screws and if a solid core insert placed inside a cannulated screw would have biomechanical effects similar to those of a solid core screw. Five screw designs were tested: Synthes 4.5-mm solid core and 4.5-mm cannulated and our prototype 4.0-mm solid core, 4.0-mm cannulated, and 4.0-mm cannulated with solid core insert. Biomechanical testing with 3-point bending was used to determine ultimate load, yield strength, and cycles to failure for 6 screws of each design. Ultimate load, yield strength, and cycles to failure were significantly (P .05) in ultimate load, yield strength, or cycles to failure between the prototype cannulated screws with solid core inserts and the prototype solid core screws.