Distribution and prognostic value of Arg753Gln TLR-2, Leu412Рhe TLR-3, Asp299Gly TLR-4 genes polymorphism in case of grippe have been studied in the present article. The examination has comprised 112 patients with grippe including 63 cases with uncomplicated course and 49 cases with grippe-associated pneumonia. The population control group has included 90 scarcely healthy persons to study Arg753Gln TLR-2 gene polymorphism and 80 ones to study Leu412Phe TLR-3 gene polymorphism. The conducted researches results have shown reliably higher frequency of heterozygous genotype Asp/Gly TLR-4 in patients with grippe (12,69%) and grippe-associated pneumonia (14,28%) compared with population control (3,33%). The frequency of homozygous genotype Phe/Phe TLR-3 in patients with grippe-associated pneumonia (18,37%) has exceeded the indices of patients with uncomplicated grippe (4,76%, р=0,02) and healthy persons (5,00%, р=0,03). Mutant genotypes combinations TLR-2, TLR-3, TLR-4 have been determined barely in patients with grippe and grippe-associated pneumonia with the frequency 11,11%-14,28%. It has been established that there is the increased risk of grippe development for persons with Asp/Gly TLR-4 genotype and TLR-2, TLR-3, TLR-4 mutant genotypes combinations; there is the increased risk of grippe-associated pneumonia for patients with mutant homozygous genotype Phe/Phe TLR-3.