Drug-gene interactions: inherent variability in drug maintenance dose requirements.

Paul, Westervelt; Kihoon, Cho; David R, Bright; David F, Kisor

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Article . 2014

Data sources: Europe PubMed Central

Drug-gene interactions: inherent variability in drug maintenance dose requirements.

descriptionPublicationkeyboard_double_arrow_right Article 11 Sep 2014 English Journal:P & T : a peer-reviewed journal for formulary management, volume 39 (issn: 1052-1372,

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Authors: Paul, Westervelt; Kihoon, Cho; David R, Bright; David F, Kisor;

pmid: 25210416

pmc: PMC4159057

Drug-gene interactions: inherent variability in drug maintenance dose requirements.

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Abstract

The influence of genetics on pharmacokinetics can introduce variability among individual patients that may cause treatment failure, toxicity, or both. Such variability, specifically in clearance rates, can influence drug maintenance dosing regimens.

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