To analyze the relation of virulence properties and pathogenicity of Porphyromonas gingivalis (P.gingivals) isolated from Chinese patients.Based on the previous analysis of virulence properties, investigations of pathogenicity properties, including the adhesion to host cells, gingipain activities, and resistance to host immune reaction were performed to analyze the diversity of pathogenic properties of these strains. SAS 8.02 software package was used for statistical analyses.Less-virulent type strain showed higher adherence ability to host red blood cells and weaker resistance to serum killing, while virulent type strain showed the opposite reactions. However, the clinic isolates presented just the opposite relationship between virulence properties and pathogenicity. In addition, there was no obvious correlation between gingipain activities and virulence properties of P. gingivalis strains.The results suggested that there is no obvious linkage between the P. gingivalis virulence properties and pathogenicity diversity.