Spectrophotometric method for estimation of bisoprolol fumarate in tablets.

Alina Diana, Panainte; Nela, Bibire; Gladiola, Tântaru; M, Apostu; Mădălina, Vieriu; V, Dorneanu

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Revista Medico-Chirurgicala

Article . 2014

Data sources: Europe PubMed Central

Spectrophotometric method for estimation of bisoprolol fumarate in tablets.

descriptionPublicationkeyboard_double_arrow_right Article 10 Oct 2014 English Journal:Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, volume 118 (issn: 0048-7848,

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Authors: Alina Diana, Panainte; Nela, Bibire; Gladiola, Tântaru; M, Apostu; Mădălina, Vieriu; V, Dorneanu;

pmid: 25076731

Spectrophotometric method for estimation of bisoprolol fumarate in tablets.

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Abstract

Bisoprolol fumarate is prescribed for the treatment of hypertension and angina pectoris.The purpose of this study was to develop a simple, sensitive, accurate, and reproducible method for estimation of bisoprolol fumarate in tablets.The proposed method was based on a yellow colored complex formed with tropaeolin 00, extractable in dichloromethane with maximum absorbance at 412 nm. The method was validated statistically.The linearity domain was observed in the concentration of 5-30 microg/ml. The recovery studies confirmed the accuracy of the proposed method.The proposed method can be applied for the routine analysis of bisoprolol from formulations.

Keywords

Dosage Forms, Methylene Chloride, Benzenesulfonates, Reproducibility of Results, Drug Combinations, Spectrophotometry, Bisoprolol, Coloring Agents, Azo Compounds, Antihypertensive Agents, Tablets

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