Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.
Copyright policy )Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.
The interleukin-2 receptor alpha (IL-2R alpha) chain gene contains a sequence similar to the immunoglobulin (Ig) kappa (kappa) enhancer NF-kappa B binding site. This site, which is bound by the nuclear protein, NF-kappa B, is critical for Ig kappa gene expression. The major T cell nuclear factor that binds to the IL-2R alpha site in vitro appears indistinguishable from NF-kappa B. NF-kappa B binds to IL-2R alpha and kappa sequences with similar affinities; however, only the kappa site potently activates transcription from heterologous promoters. Thus, high-affinity NF-kappa B binding in vitro cannot be equated with transcriptional activation in vivo. Mutation of the NF-kappa B binding site in the context of an IL-2 R alpha promoter construct markedly diminished promoter activity in human T cell lymphotropic virus type I (HTLV-I)-transformed MT-2 cells but not in phorbol myristate acetate-stimulated Jurkat T cells.
Human T-lymphotropic virus 1, Binding Sites, Base Sequence, T-Lymphocytes, Molecular Sequence Data, NF-kappa B, Receptors, Interleukin-2, DNA-Binding Proteins, Immunoglobulin kappa-Chains, Mice, Enhancer Elements, Genetic, Gene Expression Regulation, Mutation, HIV-1, Animals, Humans, Tetradecanoylphorbol Acetate, Promoter Regions, Genetic, Cell Line, Transformed, HeLa Cells
Human T-lymphotropic virus 1, Binding Sites, Base Sequence, T-Lymphocytes, Molecular Sequence Data, NF-kappa B, Receptors, Interleukin-2, DNA-Binding Proteins, Immunoglobulin kappa-Chains, Mice, Enhancer Elements, Genetic, Gene Expression Regulation, Mutation, HIV-1, Animals, Humans, Tetradecanoylphorbol Acetate, Promoter Regions, Genetic, Cell Line, Transformed, HeLa Cells
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