Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.

A.C.M. Prigitano; M.C. Esposto; M. Cogliati; L. Pitzurra; C. Santamaria; A.M. Tortorano

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Article . 2014

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Article . 2014

Data sources: Europe PubMed Central

Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2014 Italy English Journal:The new microbiologica, volume 37 (issn: 1121-7138,

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Authors: A.C.M. Prigitano; M.C. Esposto; M. Cogliati; L. Pitzurra; C. Santamaria; A.M. Tortorano;

pmid: 24858652

handle: 2434/236052

Acquired echinocandin resistance in a Candida krusei blood isolate confirmed by mutations in the fks1 gene.

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Abstract

We describe a case of bloodstream infection caused by a Candida krusei strain that developed echinocandin resistance during caspofungin therapy. Three mutations were found in the HS1 region of the fks1 gene, two of them have never been reported either in C. krusei nor in C. albicans.

Country

Italy

Related Organizations

University of Milan
Italy

Keywords

Male, Antifungal Agents, Candida krusei; Echinocandin resistance; Gene mutation, Candidiasis, Microbial Sensitivity Tests, Fungal Proteins, Echinocandins, Blood, Glucosyltransferases, Mutation, Humans, Fungemia, Aged, Candida

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