[Monoclonal antibodies against the beta subunit of human chorionic gonadotropin].
Copyright policy )[Monoclonal antibodies against the beta subunit of human chorionic gonadotropin].
The aim of investigation was creation of hybridomas, which produce monoclonal antibodies to the beta-subunit of human chorionic gonadotropin (beta-hCG), characterization of monoclonal antibodies, which necessary for hCG immunoassay in biological fluids, as an immunological methods of detection of early stage of pregnancy and choriocarcinoma. 4 hybridomas, producing monoclonal antibodies to-hCG of IgG1 isotype, were created. On the base of monoclonal antibodies, which produced by D2 hybridoma cell line, test-systems for RIA of hCG in blood serum and urine were elaborated. These test-systems can be used in medical practice for diagnosis of early stages of pregnancy and choriocarcinoma.
Mice, Inbred BALB C, Hybridomas, Pregnancy Tests, Immunologic, Antibodies, Monoclonal, Trophoblastic Neoplasms, Chorionic Gonadotropin, Peptide Fragments, Immunoglobulin Isotypes, Mice, Antibody Specificity, Pregnancy, Uterine Neoplasms, Animals, Humans, Chorionic Gonadotropin, beta Subunit, Human, Female, Immunization
Mice, Inbred BALB C, Hybridomas, Pregnancy Tests, Immunologic, Antibodies, Monoclonal, Trophoblastic Neoplasms, Chorionic Gonadotropin, Peptide Fragments, Immunoglobulin Isotypes, Mice, Antibody Specificity, Pregnancy, Uterine Neoplasms, Animals, Humans, Chorionic Gonadotropin, beta Subunit, Human, Female, Immunization
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