[Pharmacokinetics and bioavailability of ginsenoside Rg1 in rats].
Copyright policy )[Pharmacokinetics and bioavailability of ginsenoside Rg1 in rats].
To investigate the pharmacokinetics and bioavailability of ginsenoside Rg1 in rats.Ginsenoside Rg1 was oral administered or intravenous administered to each rat. The plasma concentration of ginsenoside Rg1 was estimated by RP-HPLC. 3P97 software was used to calculate pharmacokinetic parameters.Main parameters of ginsenoside Rg1 after oral or intravenous administered were: AUC(0 --> t), 322.70 +/- 20.78, 99.76 +/- 8.91 microg x h/mL, CL 0.08 +/- 0.02, 3.01 +/- 0.69 L/(kg x h), V 0.23 +/- 0.01, 22.75 +/- 2.09 L/kg, t1/2alpha 0.48 +/- 0.18, 0.87 +/- 0.21 h, t1/2beta 19.57 +/- 2.81, 18.68 +/- 2.74 h, MRT6.91 +/- 0.99, 8.15 +/- 1.05 h(-1), respectively. The relative oral bioavailability of ginsenoside Rg1 was 2.5%.The oral bioavailability of ginsenoside Rg1 is very low.
- Guangxi Traditional Chinese Medical University China (People's Republic of)
- Guangxi Medical University China (People's Republic of)
Male, Plants, Medicinal, Ginsenosides, Administration, Oral, Biological Availability, Panax, Rats, Random Allocation, Area Under Curve, Animals, Rats, Wistar, Infusions, Intravenous, Chromatography, High Pressure Liquid, Drugs, Chinese Herbal
Male, Plants, Medicinal, Ginsenosides, Administration, Oral, Biological Availability, Panax, Rats, Random Allocation, Area Under Curve, Animals, Rats, Wistar, Infusions, Intravenous, Chromatography, High Pressure Liquid, Drugs, Chinese Herbal
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