The AA, reported the effect of a therapeutic medication with toltrazuril on control of coccidiosis and broiler performance in absence of coccidiostat medicated feed. A total of 250.000 broilers of three different poultry farms were treated with toltrazuril at 7 mg/BW daily in the drinking water at 19 and 20 days of age. Oocysts monitoring in the faeces starting from the first week of age has been carried on at weekly intervals till the slaughter. The toltrazuril single treatment controlled coccidiosis and oocysts shedding that dropped at 35 days of age. Our results further indicate that in case of early coccidiosis challenge the treatment should be anticipated between 10-14 days in order to avoid early coccidiosis damages.