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Influenza della ouabaina sulla frequenza di oscillazione spontanea del pacemaker cardiaco, e sulla attività sincrona

Authors: A. Ferroni; D. Di Francesco; G. Monticelli;

Influenza della ouabaina sulla frequenza di oscillazione spontanea del pacemaker cardiaco, e sulla attività sincrona

Abstract

È stato analizzato il comportamento delle cellule vere-pacemaker del cuore di coniglio in presenza di varie concentrazioni di ouabaina allo scopo di verificare l’influenza di un trasporto attivo ionico sulla oscillazione (massimo potenziale diastolico) e la frequenza delle oscillazioni in cellule del pacemaker. In particolare, sono state rilevate le curve della frequenza in funzione della temperatura della soluzione perfondente in presenza ed in assenza di ouabaina. Inoltre, si sono fatte registrazioni continue dei potenziali d’azione di una cellula perfusa in Tyrode e Tyrode + ouabaina misurando la massima iperpolarizzazione della cellula durante l’oscillazione spontanea e l’effetto del farmaco sull’attività sincrona del pool in funzione del tempo di perfusione in Tyrode + ouabaina a temperatura costante, flusso costante e concentrazione (costante) del farmaco. I risultati ottenuti indicano che la ouabaina in concentrazione di 10-7-5·10-5 mM/l influenzano ambedue i parametri della retta f (T°) e precisamente si ha un aumento della pendenza e dei valori assoluti della frequenza nell’ambito delle temperature analizzate (28 °C-38 °C).

Country
Italy
Related Organizations
Keywords

cellule pacemaker; ouabaina; potenziale diastolico; potenziale d’azione; massima iperpolarizzazione; attività sincrona

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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