Preliminary results of trials evaluating peach cultivar resistance to Plum pox virus (PPV) and aphid colonization were obtained. Data after one vegetative cycle since an inoculation assay showed that most of the peach cultivars analyzed were susceptible to PPV-M isolate, used as inoculum source. Also, in our experiments two cultivars, Ambra and Cappucci 18, were found to be tolerant while cultivars Fei Cheng, Harrow Blood, Jing Yu and Rosa Dardi were resistant. Moreover, to evaluate the possible epidemiological impact of the peach cultivars NJ WEEPING and S6699 resistant to aphid colonization, experimental transmissions were carried out. This was done by using a clonal culture of Myzus persicae (Sulzer) as vector and PPV-M isolate as inoculum source under controlled acquisition access period. The results showed that in our conditions aphids were not able to transmitted PPV-M isolate to healthy plants of NJ WEEPING and S6699. Under the same conditions PPV-M was transmitted by aphids from infected to healthy GF305 plants.