Combined deficiency of FV and FVIII and factor VIII replacement; Dosage choice and treatment modalities of bleeding episodes - bleeding types, FV of affected individuals and FV plasma half-life; Factor V (FV), one essential nonenzymatic cofactor of prothrombinase complex; Factor V and combined factor V and VIII deficiencies; Factor V protein and gene structure; Human FV deficiency, autosomal recessive bleeding disorder; Human FV, synthesized by hepatocytes and megakaryocytes; Molecular characterization, carrier detection and prenatal diagnosis - prevention of birth of children affected by coagulation disorders; Nonsense-mediated mRNA decay (NMD) pathway; Nucleotide sequence flanking initiator ATG codon (AGCATGT) - as consensus Kozac translation initiator sequence