Guillain-Barre syndrome is an acute, or more often, a subacutely evolving paralytic disease of unestablished etiology. The condition is often designated as the Landy-Guillain-Strohl syndrome in recognition of the description provided by Landy in 1859 and again in 1916 by Guillain, Barre and Strohl. The pathogenesis and specific therapy in this condition remains imperfectly defined. The diagnosis is usually clinical with supportive laboratory tests. In this syllabus, we review the diagnostic criteria in Guillain-Barre syndrome and current therapies in the acute management followed by presentation of the acute management protocol used in the Neurosciences Department at the Riyadh Armed Forces Hospital.