Effects of selenalysine on CHO cells.

CINI, Chiara; COCCIA, Raffaella; C. Foppoli; M. Canini; M. D. Girolamo

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Archivio della ricerca- Università di Roma La Sapienza

Article . 1986

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https://pubmed.ncbi.nlm.nih.go...

Article . 1986

Data sources: Europe PubMed Central

Effects of selenalysine on CHO cells.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1986 Italy English Publisher:LUIGI PONZIO E FIGLIOJournal:Microbiologica, volume 9 (issn: 0391-5352,

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Authors: CINI, Chiara; COCCIA, Raffaella; C. Foppoli; M. Canini; M. D. Girolamo;

pmid: 2419738

handle: 11573/466449

Effects of selenalysine on CHO cells.

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Abstract

Selenalysine, the lysine isolog with the 4-methylene group substituted by a Selenium atom, inhibits growth rate and plating efficiency of Chinese Hamster Ovary (CHO) cells. It does not affect DNA and RNA synthesis, but inhibits protein synthesis. Cells grown in the presence of selenalysine show a reduced viability and an increased cell volume. Almost all the effects of selenalysine on CHO cells can be reversed by lysine, thus indicating that selenalysine acts mainly in competition with lysine by impairing its utilization.

Country

Italy

Related Organizations

Sapienza University of Rome
Italy

Keywords

Cell Survival, Lysine, Ovary, DNA, Cell Line, Kinetics, Selenium, Cricetulus, Cricetinae, Organoselenium Compounds, Protein Biosynthesis, Animals, RNA, Female, analogs /&/ derivatives/pharmacology; biosynthesis; organoselenium compounds; ovary; pharmacology; protein biosynthesis; rna; selenium, Cell Division

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