Based on correlation analysis of stroke, recorded in Khanty-Mansiysk during 5 years, and standard meteorological factors, we found the significant relationship between the frequency of stroke and daily temperature amplitude. The positive correlation between the frequency of stroke and between-day changes in air temperature in the combination with changes in atmospheric pressure during 3 h was identified. A maximal number of strokes was recorded in December, April, May and July and a minimal number was in January, June, August and September. The frequency of stroke and fatal outcomes did not depend on the season.