The history of uniportal Video-assisted thoracic surgery (VATS) stretches back almost a decade with the treatment of simple thoracic conditions. As the technique matures with increasing ability to tackle the full spectrum of thoracic surgical diseases, most notably major lung resections for lung tumours, the spread of uniportal VATS across the globe has been phenomenal. VATS centres in Asia are now performing uniportal VATS, and developing their individual styles and techniques with great successes. The enthusiasm from surgeons, demand from patients, as well as the dynamism and diversity of uniportal VATS in the region have helped fuel this excitement and change. The 1st Asian Single Port VATS Symposium in 2013 heralded the beginning of academic exchange between uniportal VATS centres in Asia and experts from around the world. Wetlabs in the region will provide further training for thoracic surgeons interested in super-specializing in uniportal VATS. The future of this approach will hinge on good regional collaboration, research and training.