Heated Intraoperative Intraperitoneal Chemotherapy (HIPEC) offers a chance for extended survival, or cure, to patients facing specific types of invasive abdominal cancer. This article will explore the perioperative facets of implementing a peritoneal malignancy program that includes the HIPEC procedure. In exploring this procedure, experiences will be shared with the intent of optimizing patient care for potential surgical programs and perioperative staff. The examination will illustrate the respective program development areas such as training, budgetary requirements and patient care considerations. Further, the dialogue will investigate patient selection, preoperative preparation and intraoperative considerations. Lastly, the article will reveal the specific shortterm and long-term patient outcomes starting with the immediate postoperative phase.