Current study is aiming at comparative characterization of clinical aspects of preparations, containing calcium hydroxide, in the treatment of pulp hyperemia (primary pulpitis). With this aim two products, made on the base of calcium hydroxide, were selected: Ultra-Blend (Ultradent) and Life (Kerr). The results obtained after application of these materials were compared with the results obtained in patients affected with the similar pathology, where Ca(OH)2 containing liners were not used in treatment process. 54 teeth were selected for the study, among them - 38 molars and 16 premolars. Patients were divided into three groups: I group (21 teeth) included the patients who underwent pulp hyperemia treatment with Life, II group - patients treated with Ultra-Blend (19 teeth) and III group - patients without any pulp protections respectively (13 teeth). It was decided to perform treatment assessment and making appropriate conclusions according to two factors: degree of adhesion of restorations to teeth surfaces and teeth post-restorative sensitivity. Comparison of the obtained data of study and control groups revealed weakening of adhesion between filling and tooth tissues practically in all 3groups, however, with different rate and intensity: in I group on radioography micro cracks were revealed in 10 cases (47.6%), II group -7 (36.5%) cases and treating group - 4 (30.7%) cases, respectively. The obtained results of the current study revealed non-homogenous picture: in I group where Kerr liner was applied - hypersensitivity was revealed in 12 (57.1%) cases, II group - 6 (31.5%) and III group - 7 (53.8%) cases. It is concluded that the primary reason for teeth prolonged and enhanced sensitivity is a micro-percolation factor into the perimeter. But if we admit the application of medical liners in the treatment of pulp hyperemia, doctor's choice should be made on those, providing maximum prevention of further complications. At this stage of the study such features were better revealed by Ultra-Blend. However, the final clinical outcomes - pulp hyperemia disappearance, no complains, production of tertiary dentin and so on - might be expected within a year after the end of the treatment. Currently, it will be interesting to study the pulp chamber condition, evaluation of electrophysiological parameters of the tooth and restoration quality. The mentioned issues will be studied in the future studies.