Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.
Copyright policy )Mannose binding lectin and mannose binding lectin-associated serine protease-2 genes polymorphisms in human T-lymphotropic virus infection.
Variations in genes involved in the immune response pathways may influence the interaction between viruses (such as Human T-lymphotropic virus, HTLV-1) and the host. The mannose binding lectin (MBL) and its associated serine protease type 2 (MASP-2) promote the activation of the lectin pathway of the complement system. As the interaction of complement system with HTLV-1 is not well understood, the MBL2 promoter/exon 1 polymorphisms and a MASP2 missense polymorphism were examined in a Northeast Brazilian population, looking for a possible relationship between these variations and the susceptibility to HTLV-1 infection. The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. These findings suggest an important role of the complement system activation, via the lectin pathway, in the susceptibility to HTLV-1 infection.
- University of Trieste Italy
- Universidade Federal de Pernambuco Brazil
- University of Ferrara Italy
Adult, Male, Mutation, Missense, Mannose-Binding Lectin, HTLV; Innate immunity; MASP2; MBL2; SNPs;, Young Adult, Humans, Genetic Predisposition to Disease, Promoter Regions, Genetic, Polymorphism, Genetic, MBL2; HTLV-1; MASP2; SNPs, Complement System Proteins, Exons, Middle Aged, HTLV-I Infections, MBL2, MASP2, HTLV-1, Mannose-Binding Protein-Associated Serine Proteases, Female, Brazil, SNPs
Adult, Male, Mutation, Missense, Mannose-Binding Lectin, HTLV; Innate immunity; MASP2; MBL2; SNPs;, Young Adult, Humans, Genetic Predisposition to Disease, Promoter Regions, Genetic, Polymorphism, Genetic, MBL2; HTLV-1; MASP2; SNPs, Complement System Proteins, Exons, Middle Aged, HTLV-I Infections, MBL2, MASP2, HTLV-1, Mannose-Binding Protein-Associated Serine Proteases, Female, Brazil, SNPs
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