[The antitoxic function of the liver in D-galactosamine poisoning].
Copyright policy )[The antitoxic function of the liver in D-galactosamine poisoning].
Two intragastric administrations of 500 mg/kg of D-galactosamine reduce the RNA and the cytochrome P-45, and b5 content in the hepatic microsomes of rats; inhibit the activity of aminopyrine-N-demethylase, hexobarbital hydroxylase, aniline-p-hydroxylase, and glutathione-S-transferase; reduce the rate of NADP.H and NAD.H oxidation; accelerate inactivation of cytochrome P-450 to cytochrome P-420; reduce the number of points of hexobarbital binding with N-octilamine, though increase the hemoprotein affinity to these substrates. Destruction of the nucleus, endoplasmic reticulum, and mitochondria occurs in the hepatocytes of D-galactosamine poisoned rats.
Male, Microscopy, Electron, Liver, Microsomes, Liver, Animals, Galactosamine, Biotransformation, Rats
Male, Microscopy, Electron, Liver, Microsomes, Liver, Animals, Galactosamine, Biotransformation, Rats
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