[Biocompatibility and pharmacokinetics of hydroxypropyl methylcellulose (HPMC) in the anterior chamber of the rabbit eye].

W, Ehrich; H, Höh; C F, Kreiner

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Klinische Monatsblät...arrow_drop_down

Klinische Monatsblätter für Augenheilkunde

Article . 1990

Data sources: Europe PubMed Central

[Biocompatibility and pharmacokinetics of hydroxypropyl methylcellulose (HPMC) in the anterior chamber of the rabbit eye].

descriptionPublicationkeyboard_double_arrow_right Article 04 Sep 1990 German Journal:Klinische Monatsblatter fur Augenheilkunde, volume 196 (issn: 0023-2165,

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Authors: W, Ehrich; H, Höh; C F, Kreiner;

pmid: 2376944

[Biocompatibility and pharmacokinetics of hydroxypropyl methylcellulose (HPMC) in the anterior chamber of the rabbit eye].

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Abstract

The biocompatibility and pharmacokinetics of hydroxypropylmethylcellulose (HPMC) 2% (Adatocel) and Tylose 2% (MH 1000) were investigated. A modified anterior chamber implantation test on the rabbit eye is suitable for testing both the biocompatibility and the pharmacokinetics of visco-surgical substances. Both substances were well tolerated. From the fourth day onward, HPMC was no longer detectable in the anterior chamber by infrared spectroscopy.

Related Organizations

Augenklinik Universitätsallee
Germany

Keywords

Male, Spectrophotometry, Infrared, Anterior Chamber, Biocompatible Materials, Methylcellulose, Hypromellose Derivatives, Animals, Female, Rabbits

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