[Selective progesterone receptor modulators and their therapeutical use].
Copyright policy )[Selective progesterone receptor modulators and their therapeutical use].
Currently developed selective progesterone receptor modulators (SPRMs) are steroid derived compounds with a bulky radical substitution at carbon 11. They interact with progesterone receptor and exert antagonistic or/and agonistic effects. Mifepristone was approved for pregnancy termination and ulipristal acetate as emergency contraception and pharmacological therapy of uterine fibroids. SPRMs inhibit endometrial proliferation and myoma growth, this suggests a therapeutical effect in cases of endometriosis and other estrogen-dependent diseases.
Norpregnadienes, Leiomyoma, Endometriosis, Abortion, Induced, Mifepristone, Hormone Antagonists, Pregnancy, Humans, Female, Receptors, Progesterone, Progesterone
Norpregnadienes, Leiomyoma, Endometriosis, Abortion, Induced, Mifepristone, Hormone Antagonists, Pregnancy, Humans, Female, Receptors, Progesterone, Progesterone
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