We present the case of 51 year old man with 10 year history of ulcerative colitis. Results of laboratory test revealed increased serum levels of iron, ferritin as well as moderate hiperbilirubinemia. Transferrin saturation index was high, 98,7% (N< 50%). Long lasting remission of inflammatory bowel disease, including lack of bleeding from gastrointestinal tract disclosed hereditary hemochromatosis presence in that patient.