[Oxidative damage to the myocardium: the protective action of exogenous phosphocreatine].

E A, Konorev; V A, Saks; V G, Sharov; L A, Makhotina

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Bulletin of Experime...arrow_drop_down

Bulletin of Experimental Biology and Medicine

Article . 1990

Data sources: Europe PubMed Central

[Oxidative damage to the myocardium: the protective action of exogenous phosphocreatine].

descriptionPublicationkeyboard_double_arrow_right Article 15 Aug 1990 Russian Journal:Biulleten' eksperimental'noi biologii i meditsiny, volume 109 (issn: 0365-9615,

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Authors: E A, Konorev; V A, Saks; V G, Sharov; L A, Makhotina;

pmid: 2364142

[Oxidative damage to the myocardium: the protective action of exogenous phosphocreatine].

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Abstract

Oxidative damage of the isolated perfused rat heart was caused by addition of 90 microM H2O into Krebs-Henseleit solution. After 20 min of H2O2 addition an elevation of diastolic pressure (irreversible contracture) was observed followed by decrease of developed tension and heart work. Addition of phosphocreatine (10 mM) at constant total sodium concentration prevented the development of contracture and diminished the decrease of cardiac work. This protective effect is probably related to the elevation of structural order of phospholipids by phosphocreatine.

Keywords

Male, Phosphocreatine, Myocardium, Drug Evaluation, Preclinical, Heart, Myocardial Reperfusion Injury, Rats, Inbred Strains, Hydrogen Peroxide, In Vitro Techniques, Myocardial Contraction, Rats, Perfusion, Microscopy, Electron, Animals

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