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Hypohidrosis and hyperthermia during topiramate treatment in children.

Name: Hypohidrosis and hyperthermia during topiramate treatment in children.
Keywords: Hypohidrosis, Male, Dose-Response Relationship, Drug, Fever, Turkey, Incidence, Infant, Fructose, Pediatrics, RJ1-570

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2012 Turkey English Publisher:Hacettepe University Institute of Child HealthJournal:The Turkish journal of pediatrics, volume 54 (issn: 0041-4301,

Authors: Incecik F.; Özlem Hergüner M.; Altunbaşak Ş.;

pmid: 23427516

handle: 20.500.12605/16025

Hypohidrosis and hyperthermia during topiramate treatment in children.

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Abstract

Topiramate is one of the newer generation antiepileptic drugs with a beneficial clinical effect on various seizure types. In this study, we present the clinical findings of hypohidrosis and hyperthermia with topiramate in pediatric patients. The data were collected retrospectively on 173 patients diagnosed as epilepsy on topiramate treatment, and hypohidrosis-related symptoms induced by topiramate were found in 22 patients. Their mean age was 64.45±56.63 months. The mean duration of topiramate treatment was 7.09±2.46 months, and the mean dose was 5.37±1.75 mg/kg/day. All of the patients complained of hypohidrosis and hyperthermia. Six (27.2%) of them had facial flushing, 4 (18.1%) had heat sensation and only 1 (4.5%) had lethargy. Hypohidrosis-related symptoms resolved after discontinuation of the medication. In conclusion, children treated with topiramate should be cautioned regarding these potential adverse effects and advised to avoid its use during the hot summer season.

PubMedID: 23427516

Country

Turkey

Related Organizations

Cukurova University
Turkey

Keywords

Hypohidrosis, Male, Dose-Response Relationship, Drug, Fever, Turkey, Incidence, Infant, Fructose, Pediatrics, RJ1-570, Risk Factors, Seizures, Topiramate, Child, Preschool, Humans, Hyperthermia, Anticonvulsants, Female, Child, Children, Follow-Up Studies, Retrospective Studies

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