Bipolar disorders are linked to a high suicidal risk. Many risk factors are identified but it seems relevant to highlight the relationship between suicidal behavior and the different subtypes of bipolar disorder, or the different kinds of outcomes, or the clinical characteristics of a recurrence. A high frequency of depressive episodes in the story of the illness, like in predominant depressive polarity forms, or mixed features during symptomatic recurrences seem to be linked to a higher suicidal risk in the course of the disorder. Underlying mechanisms are yet to be identified. The investigation of these specifics lead into considering specific therapeutic actions based upon the clinical identification of mixed symptomatology during a recurrence for a tailored treatment or a thorough screening and assessment of depressive states during the course of the bipolar illness in order to try to prevent them.