Sulphamethoxazole acetylation in fast and slow acetylators.
Copyright policy )Sulphamethoxazole acetylation in fast and slow acetylators.
Acetylation of sulphamethoxazole was studied in 22 subjects previously phenotyped with sulphadimidine. Sulphamethoxazole and its acetylated metabolite were measured in 6 h plasma and 0-6 h urine samples. Percentage of plasma acetylated-sulphamethoxazole did not correlate with the percentage of urinary acetylated-sulphamethoxazole. There was also no correlation between the percentage of acetylated-sulphadimidine and percentage of acetylated-sulphamethoxazole in plasma. The finding suggest that the acetylation of sulphamethoxazole has no predictive value in determining acetylator status.
- Hacettepe University Turkey
Adult, Male, Sulfamethoxazole, Acetylation, Sulfamethazine, Middle Aged, Phenotype, Humans, Female, Aged
Adult, Male, Sulfamethoxazole, Acetylation, Sulfamethazine, Middle Aged, Phenotype, Humans, Female, Aged
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