71 patients were under the observation (37 male and 34 female) aged 30-74 years old (average age 51). Depression developed after 3-6 months after the cranial injury. 20 patients with vertebrogeneous lumbargy without injury were included into the comparing group. Neurological, pathopsycological and psychometric examination were carried out (according to Gamilton's, Bek's, Spilberger-Hanyn's scales). It was demonstrated that average depression level in patiens after cranial injury was the same as in patients without injury and it didn't depend on injury terms and neurological deficiency. Clinicaly manifested, severe, depression was noticed in 22% patients. Its degree was higher in cases of the right hemisphere localization of traumatic process. It was determined that psycosocial factors (lonlines) were the most significant for depression pathogenesis. Conditions of depression occurences were aftertraumatic intellect and high anxiety level. Loss of job didn't influence the patients condition.