Genotyping of clinical Mycobacterium tuberculosis isolates based on eight loci of MIRU-VNTR.

R X, Liu; Q Z, Li; L L, Xing; Z, Peng; C M, Zhu; Z H, Yang

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The International Jo...arrow_drop_down

The International Journal of Tuberculosis and Lung Disease

Article . 2013

Data sources: Europe PubMed Central

Genotyping of clinical Mycobacterium tuberculosis isolates based on eight loci of MIRU-VNTR.

descriptionPublicationkeyboard_double_arrow_right Article 02 Jul 2013 English Journal:The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, volume 17 (issn: 1815-7920,

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Authors: R X, Liu; Q Z, Li; L L, Xing; Z, Peng; C M, Zhu; Z H, Yang;

pmid: 23317961

Genotyping of clinical Mycobacterium tuberculosis isolates based on eight loci of MIRU-VNTR.

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Abstract

Genotyping that differentiates between strains of Mycobacterium tuberculosis based on variations in the genome of the organism is a useful tool for molecular epidemiological studies of tuberculosis. In the present study, we identified a combination of five mycobacterial interspersed repetitive unit (MIRU) loci and three variable numbers of tandem repeats (VNTR) loci of M. tuberculosis that showed a discriminatory power comparable to that of the 15 to 24 loci-based typing proposed for international standardisation in analysing 210 paediatric isolates obtained from Chongqing, China.

Related Organizations

Children's Hospital of Chongqing Medical University
China (People's Republic of)

Keywords

DNA, Bacterial, Genotype, Sputum, Humans, Tuberculosis, Minisatellite Repeats, Mycobacterium tuberculosis, Child, Polymerase Chain Reaction, Bacterial Typing Techniques

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