Oseltamivir analog with boron cluster modulator.

Authors: Adamska, Anna; Olejniczak, Agnieszka; Zwoliński, Krzysztof; Szczepek, Wojciech; Ewelina Król; Bogusław Szewczyk; Grynkiewicz, Grzegorz; +1 Authors

pmid: 23285684

Oseltamivir analog with boron cluster modulator.

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Abstract

Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding ethyl ester, which is the active principle of pharmaceutical preparations used in influenza prophylactics and therapy.

Country

Poland

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Keywords

neuraminidase inhibitor, Neuraminidase, Antiviral Agents, Cell Line, Structure-Activity Relationship, Dogs, Oseltamivir, oseltamivir analog, antiviral activity, Animals, carborane cluster, Boron

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