Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran.
Copyright policy )Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran.
Ankylosing spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population.The study group comprised 387 Iranian AS patients and 316 healthy controls from Iran. Using Real Time PCR allelic discrimination method, we genotyped four SNPs (rs30187, rs469876, rs13167972 and rs27434) of ERAP1. We found that rs30187 and rs27434 were significantly associated with AS in Iranian population (P=6×10-5, P=7×10-3, respectively). The rs30187 T/T genotype was associated with AS compared with C/C genotype (P=1.5×10-5). The rs27434 G/G genotype was inversely associated with AS (P=5×10-3). Two specific haplotypes including: rs30187/ rs469876/ rs13167972/ rs27434 TAAA and CAGG were associated with increased and decreased risk of AS in Iranian population, respectively. These results indicated that ERAP1 SNPs and haplotypes were associated with AS in Iranian population.
- Tehran University of Medical Sciences Iran (Islamic Republic of)
Adult, Male, Ankylosing Spondylitis, Iran, Endoplasmic Reticulum, Aminopeptidases, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Risk Assessment, Minor Histocompatibility Antigens, Gene Frequency, Odds Ratio, Humans, Genetic Predisposition to Disease, Chi-Square Distribution, R, Middle Aged, Aminopeptidase 1, Logistic Models, Phenotype, Haplotypes, Case-Control Studies, Multivariate Analysis, Single Nucleotide Polymorphism, Medicine, Female
Adult, Male, Ankylosing Spondylitis, Iran, Endoplasmic Reticulum, Aminopeptidases, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Risk Assessment, Minor Histocompatibility Antigens, Gene Frequency, Odds Ratio, Humans, Genetic Predisposition to Disease, Chi-Square Distribution, R, Middle Aged, Aminopeptidase 1, Logistic Models, Phenotype, Haplotypes, Case-Control Studies, Multivariate Analysis, Single Nucleotide Polymorphism, Medicine, Female
citations The total number of citations received by all articles of the researcher of interest.35 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!