This 3-volume reference covers the entire field of epidemiology, from statistical methods and study design, to specialized areas such as molecular epidemiology, and applications in clinical medicine and health services research. This updated edition of the Handbook of Epidemiology adds 22 new chapters on: History of Epidemiological Methods and Concepts, Cluster Randomized Trials, Internet Based Epidemiology, Misclassification, Bias/Sensitivity Analysis, Disease Surveillance, Statistical Inference, Data Management in Epidemiology, Visual Display of Quantitative Information, Bayesian Methods in Epidemiology, Generalized Estimating Equations, Directed Acyclic Graphs, Life Course Epidemiology, Methods and Applications in Genetic Epidemiology, Physical Activity, Radiation Epidemiology, Epidemiology of Obesity, Epidemiology of Asthma and Allergies, Epidemiology of Dental Diseases, Epidemiology of Digestive Diseases, Psychiatric Disorders, Epidemiology of Diabetes. All other chapters are extensively revised from the 1st edition. This is a reference for epidemiological researchers and graduate students in public health.