All over the world motorcycle accident are one of the major causes of road death and injury. This study aimed to determine the pattern of Motorcycle Fatal Accidents in Mashhad-Iran.This descriptive cross-sectional study was carried out in 2006 to analyze the epidemiological pattern of the motorcycle accident in Mashhad, North-Eastern Iran. Three hundred fifty cases of motorcycle accidents were included. Data gathering tool was a standard questionnaire. The compiled data were analyzed using SPSS11 and χ(2) test. The significance level was considered 0.05 in all statistical tests.In the time span of the study, 350 cases of motorcycle accident occurred, most of which happened at 8pm to 12pm. In 119 cases, the motorcyclist was the blameful rider. Generally, 84.2% of the motorcycle riders did not have safety helmets. About two third of blameful motorcycle riders (63.1%) were less than 25 years old. The major cause of the accidents (55.1%) was due to neglecting the Yield Right of Way. Motorcycle riders endanger pedestrian, other drivers, passengers and their own life.Paying attention to cultural and instructional issues of correct motorcycle riding and performing appropriate monitoring in traffic and transportation system such as honoring our and others safety and setting limitations on using this vehicle by the youth is of great importance.