[Research progress of protein tyrosine phosphatase SHP-2].

Hong-ke, Cai; Yong-chuan, Deng

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Journal of Zhejiang University (Medical Sciences)

Article . 2013

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[Research progress of protein tyrosine phosphatase SHP-2].

descriptionPublicationkeyboard_double_arrow_right Article 14 Mar 2013Journal:Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, volume 41 (issn: 1008-9292,

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Authors: Hong-ke, Cai; Yong-chuan, Deng;

pmid: 23086654

[Research progress of protein tyrosine phosphatase SHP-2].

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Abstract

The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors. Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy.

Related Organizations

Zhejiang Ocean University
China (People's Republic of)

Keywords

Humans, Protein Tyrosine Phosphatase, Non-Receptor Type 11

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