The issues of further development of scientific and methodological basis of the guarantee of sanitary-epidemiological welfare of population of the Russian Federation are highlighted in accordance with the implementation of the Concept of the activity of the Federal Service for the Oversight of Consumer Protection and Welfare until 2015. Features of this work over the past 5 years have been characterized, they include: changes in the structure of the objects under surveillance; integration processes in the economy of the country rise of attention to social problems of society strengthening the influence of epidemiological and natural man-made disasters in the world and the country, improvement of the supervisory authorities of the Service, the formation of its new structure and development of legislative assembly, including sanitary legislation.