SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Copyright policy )SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer.
Through their roles in tissue remodeling, variants in the genes that encode alpha1-antitrypsin (AAT) and neutrophil elastase (NE) were hypothesized to be associated with the risk of both chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC).Cases with prevalent COPD (n=145), incident NSCLC (n=203) or prevalent COPD plus NSCLC (n=118) were compared to disease-free controls (n=317), to assess two functional polymorphisms in serpin peptidase inhibitor, clade A, member 1 (SERPINA1), which encodes AAT, and eleven tagging polymorphisms in and around elastase 2 (ELA2), which encodes NE. All analyses were stratified by race.Among African-Americans, the less efficient SERPINA1 variant appeared to be associated with increased risk of prevalent COPD but only in the presence of NSCLC (odds ratio=7.39; 95% confidence interval=1.03-53.21) and not after correcting for multiple comparisons.Variations in SERPINA1 and ELA2 were not consistently or strongly associated with the risk of either COPD or NSCLC in either race.
Male, Lung Neoplasms, Serine Endopeptidases, Polymorphism, Single Nucleotide, White People, Black or African American, Pulmonary Disease, Chronic Obstructive, Carcinoma, Non-Small-Cell Lung, Case-Control Studies, alpha 1-Antitrypsin, Humans, Female, Leukocyte Elastase, Aged
Male, Lung Neoplasms, Serine Endopeptidases, Polymorphism, Single Nucleotide, White People, Black or African American, Pulmonary Disease, Chronic Obstructive, Carcinoma, Non-Small-Cell Lung, Case-Control Studies, alpha 1-Antitrypsin, Humans, Female, Leukocyte Elastase, Aged
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