Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
Copyright policy )Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma.
G protein beta subunit (Gbeta2) is over-expressed in Zajdela ascitic hepatoma (ZAH), a rat ascitic tumour, at mRNA as well as protein levels. Nuclear run-off transcription analysis suggests that the expression of Gbeta2 in ZAH is regulated mainly at transcriptional as well as post-transcriptional levels. Galphai3 is also over-expressed in ZAH. No amplification or any change in the organization of the genes for GBbeta2 or Galphai3 was observed. It is possible that the over-expression of G protein subunits in ZAH could provide proliferative advantage to the cells by virtue of their effects on second messenger systems.
Cell Nucleus, Carcinoma, Hepatocellular, Transcription, Genetic, Gene Expression Profiling, Liver Neoplasms, Ascites, Rats, Gene Expression Regulation, Neoplastic, Liver, GTP-Binding Proteins, Cell Line, Tumor, Animals, RNA, Messenger, Dimerization, Signal Transduction
Cell Nucleus, Carcinoma, Hepatocellular, Transcription, Genetic, Gene Expression Profiling, Liver Neoplasms, Ascites, Rats, Gene Expression Regulation, Neoplastic, Liver, GTP-Binding Proteins, Cell Line, Tumor, Animals, RNA, Messenger, Dimerization, Signal Transduction
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