In the past 10 years, enterohemorrhagic Escherichia coli (EHEC) infection in infants and children has not been decreased in Japan. Clinical manifestations may include history of diarrhea, a visibly bloody stool, fever, and abdominal tenderness those last for about 2 weeks and restore naturally. However, if the patients suffer from hemolytic uremic syndrome (HUS) that may be fatal infrequently. The major treatment for EHEC infection and HUS have been therapies for these symptons. Therefore new therapeutic agents for vero toxin (VT) have been developed, but that is still experimental. We describe the latest clinical researches and treatment strategies in this paper.