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Quantitative analysis of norfloxacin by 1H NMR and HPLC.

Authors: Anita, Frackowiak; Zenon J, Kokot;

Quantitative analysis of norfloxacin by 1H NMR and HPLC.

Abstract

1H NMR and developed previously HPLC methods were applied to quantitative determination of norfloxacin in veterinary solution form for pigeon. Changes in concentration can lead to significant changes in the 1H chemical shifts of non-exchangeable aromatic protons as a result of extensive self-association phenomena. This chemical shift variation of protons was analyzed and applied in the quantitative determination of norfloxacin. The method is simple, rapid, precise and accurate, and can be used for quality control of this drug.

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Keywords

Quality Control, Magnetic Resonance Spectroscopy, Calibration, Animals, Reproducibility of Results, Veterinary Drugs, Columbidae, Chromatography, High Pressure Liquid, Anti-Bacterial Agents, Norfloxacin

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
gold
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