[Comparative study of antiviral activity of luteolin and 7,3'-disulfate luteolin].

N. V. Krylova; A. M. Popov; G. N. Leonova; A. А. Artyukov; O. S. Maistrovskaya

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Антибиотики и Химиотерапия

Article . 2020

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Антибиотики и Химиотерапия

Article . 2012

Data sources: Europe PubMed Central

[Comparative study of antiviral activity of luteolin and 7,3'-disulfate luteolin].

descriptionPublicationkeyboard_double_arrow_right Article 13 Dec 2012 Russian Publisher:LLC "Publishing House OKI"Journal:Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], volume 56 (issn: 0235-2990,

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Authors: N. V. Krylova; A. M. Popov; G. N. Leonova; A. А. Artyukov; O. S. Maistrovskaya;

pmid: 22856150

[Comparative study of antiviral activity of luteolin and 7,3'-disulfate luteolin].

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Abstract

Antiviral activity of 7,3'-disulfate luteolin, extracted from Zostera marina was studied on an experimental model of tick-borne encephalitis (TBE) in vivo and in vitro. The drug increased the survival of the experimental mice infected with TBE virus and prolonged their lifespan. It was shown that 7,3'-disulfate luteolin reduced the virus accumulation in the SPEV cells by 2.0-4.0 lg TCID50/ml.

Keywords

Male, Dose-Response Relationship, Drug, Zosteraceae, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, luteolin disulfate, Antiviral Agents, Cell Line, Encephalitis Viruses, Tick-Borne, Disease Models, Animal, Mice, antiviral activity, Animals, luteolin, tick-ьоте encephalitis virus, Luteolin, RC254-282, Encephalitis, Tick-Borne

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