The main objective was to have a view of the functioning of the Centers Memory of Resources and Research (CMRR) to identify the difficulties which can interfere in the industrial clinical trials. The secondary objective was to make a proposal to optimize them.Questionnaires were given in all CMRRs.One hundred thrity-five questionnaires were retrived (26 centers answered on the 27 that exist). Some elements appeared as strong structural factors but some weaknesses were highlighted such as: insufficient staff, lack of dedicated areas, lack of communication, activities multiplications, functional unit (UF) subdivision. CONCLUSION-PROPOSITION: After a Strenghts-Weakness-Opportunities-Threats (SWOT) analysis, we kept 3 main axis to improve: information and formation diffusion, transdisciplinary meetings establishment, better mobilization of doctors for clinical trials. We think that a special "clinical trail" unit within each CMRR should be created. It will enhance the level, the competences and the reactivtity of each clinical trial center which will lead to better collaboration with big pharmaceutical companies.